Factors Driving the Aspirin Exacerbated Respiratory Disease Phenotype
نویسندگان
چکیده
منابع مشابه
Factors driving the aspirin exacerbated respiratory disease phenotype
BACKGROUND Aspirin-exacerbated respiratory disease (AERD) is explained in part by overexpression of 5-lipoxygenase and leukotriene C4 synthase (LTC4S), resulting in constitutive overproduction of cysteinyl leukotrienes (CysLTs) and driving the surge in CysLT production that occurs with aspirin ingestion. Similarly, AERD is characterized by the overexpression of CysLT receptors. Increased levels...
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As guest editors of this special issue of the Journal of Allergy, we are pleased to be able to present a range of articles, both reviews and original research papers, on the important topic of aspirin-exacerbated respiratory disease (AERD). AERD is a synonym for the " aspirin triad " of asthma, nasal polyposis and sensitivity to aspirin originally described by Widal ninety years ago. AERD patie...
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BACKGROUND Aspirin triad is a subclass of chronic sinusitis characterized by nasal polyposis, nonallergic induced asthma, and aspirin sensitivity. Also known as Samter's triad or aspirin-exacerbated respiratory disease, aspirin triad commonly affects the adult population and is seldom found in pediatric patients. METHODS This rhinosinusitis has multiple layers of pathological process, but th...
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ژورنال
عنوان ژورنال: American Journal of Rhinology & Allergy
سال: 2015
ISSN: 1945-8924,1945-8932
DOI: 10.2500/ajra.2015.29.4123